51st Annual MIKI Meeting Schedule



Friday April 12th, 2013

3:30 - 6:30 PM Conference Registration
The Commons Hotel, Minneapolis
6:30 - 9:30 PM Social Mixer
Weisman Art Museum
(Hearty appetizers and drinks available. Museum exhibits and bar close at 9:00 PM)

Saturday April 13th, 2013

7:30 - 9:00 AM Continental Breakfast
Auditorium Atrium, Molecular and Cellular Biology Building
9:00 - 9:15 AM Opening Remarks and Welcome
Dr. Patrick E. Hanna
Professor Emeritus
Morse-Alumni Distinguished Teaching Professor
Department of Medicinal Chemistry


Session 1 Auditorium, Molecular and Cellular Biology Building
9:15 - 9:35 AM Chemically Self-Assembled Nanostructures (CSANS) for the Targeted
Cellular Delivery of Oligonucleotides, Drugs and Proteins

Amit Gangar, and Carston Rick Wagner
University of Minnesota
9:35 - 9:55 AM A Co-culture Based Approach Toward the Induction of Antibiotics to
Combat Biodefense Pathogens

Skylar Carlson, Urszula Tanouye, and Brian T. Murphy
University of Illinois at Chicago
9:55 - 10:15 AM A Co-culture Based Approach Toward the Induction of Antibiotics to
Combat Biodefense Pathogens

Skylar Carlson, Urszula Tanouye, and Brian T. Murphy
University of Illinois at Chicago
10:15 - 10:35 AM Interactions of Endoxifen and Other Metabolites of Tamoxifen with Human
Hydroxsteroid Sulfotransferase 2A1 (hSULT2A1)

Edwin J. Squirewell, and Michael W. Duffel
University of Iowa
10:35 - 10:55 AM Coffee Break

Keynote Address
10:55 - 12:00 PM Organic Chemistry and Utilizing Microbial Iron Assimilation Processes for
the Development of New Antibiotics

Dr. Marvin J. Miller
Department of Chemistry and Biochemistry, University of Notre Dame

Lunch Break
12:00 - 1:30 PM Lunch
The Commons Hotel, Minneapolis, Ballroom.
Poster Set-Up
Pathways and Inventors Room, Second Floor
The Commons Hotel, Minneapolis.

1:30 - 3:30 PM Poster Session and Vendor Exposition
Pathways and Inventor Rooms, 2nd floor, The Commons Hotel
Odd numbered posters: 1:30 - 2:30 PM
Even numbered posters: 2:30 - 3:30 PM


Session 2
3:30 - 3:50 PM Biological Characterization of Non-steriodal Progestins from Botanicals in
vitro and in vivo for Women's Health

M.F. Toh, J. Sohn, S.N. Chen, P. Yao, J.L. Bolton, D.D. Lantvit, S. I. Eddie, and
J.E. Burdette
University of Illinois at Chicago
3:50 - 4:10 PM Development of Siderophore Inhibitors as Anti-Tubercular Agents
Kathryn M. Nelson, Benjamin P. Duckworth, and Courtney C. Aldrich
University of Minnesota
4:10 - 4:30 PM Design and Synthesis of Novel N-1 Fluoroquinolone Derivatives to Explore
New Binding Contacts with Bacterial Type II Topoisomerases

Tyrell R. Towle, and Robert J. Kerns.
University of Iowa
4:30 - 4:50 PM Toll-like Receptor-8 Agonistic Activities of Furo[2,3-C]pyridines
Euna Yoo, Deepak B. Salunke, Nikunj M. Shukla, Rajalakshmi Balakrishna,
Subbalakshmi S. Maddadi, Victor W. Day, and Sunil A. David.
University of Kansas

MIKI Banquet
6:30 - 10:00 PM MIKI Banquet
Earle Brown Heritage Center
Buses begin leaving hotel at 5:45 PM - west wing entrance

Sunday April 14th, 2013

7:30 - 9:00 AM Check-out
The Commons Hotel, Minneapolis

Continental Breakfast
Auditorium Atrium, Molecular and Cellular Biology Building
Session 3
9:00 - 9:20 AM Synthesis and Bioactivation of Selective Estrogen Receptor Modulators
(SERMs) Bazedoxifene and Lasofoxifene

Bradley T. Michalsen, Teshome B. Gherezghiher, Gregory R. J. Thatcher, Judy L. Bolton
University of Illinois at Chicago
9:20 - 9:40 AM Innate C–H Functionalization of Cyclic Enaminones
Yi-Yun Yu, and Gunda I. Georg
University of Minnesota
9:40 - 10:00 AM Structural Analysis of RGS Inhibitors
Colin A. Higgins, and David L. Roman
University of Iowa
10:00 - 10:20 AM Effects of a Single Active Site Residue Mutation (A105L) on Prostate Cancer
Target Cytochrome P450 17A1

Elyse M. Petrunak, and Emily E. Scott
University of Kansas
10:20 - 10:40 AM Coffee Break

Session 4
10:40 - 11:00 PM Structure-Based Design of Novel Inhibitors for Sex Steroid Biosynthesis
Charlie Fehl, Elyse Petrunak, Emily Scott, and Jeffrey Aubé
University of Kansas
11:00 - 11:20 AM Nitric Oxide is an Epigenetic Regulator: A "Radical" Approach to Gene Regulation
Divya Vasudevan, Jason R. Hickok, William E. Antholine, and Douglas D.Thomas
University of Illinois at Chicago
11:20 - 11:40 AM Targeting the Regulator of G Protein Signaling 17 (RGS17): Development of
a Novel High-Throughput Screen and Characterization of Lead Small
Molecule Inhibitors for the Treatment of Metastatic Lung and Prostate Cancers

Duncan L. Mackie, and David L. Roman
University of Iowa
11:40 - 12:00 PM Inter-species Differences in the Metabolism of 1,3-Butadiene
Srikanth Kotapati, Dewakar Sangaraju, Amanda Esades, and Natalia Tretyakova
University of Minnesota

12:00 PM Closing of the 51st MIKI Meeting
12:15 PM Adjournment and Faculty Meeting

Lunch box pick-up
Auditorium Atrium, Molecular and Cellular Biology Building